My A1C Was 6.8. My Doctors Said I Was Well-Controlled. So Why Were My Feet Going Numb Every Month, My Gabapentin Dose Keeping Going Up, And My B12 Doing Nothing? Then One Functional Medicine Doctor Drew The Picture Nobody Had Shown Me In Eleven Years.
What This Article Covers
- Why your A1C looks perfectly fine while your nerves are being attacked 3 to 5 times a day, every single day, without you feeling it happen.
- The contrarian truth almost no endocrinologist says out loud: Gabapentin quiets the alarm, but the fire underneath keeps burning and the damage compounds year after year.
- Why the B vitamins you took from the drugstore were never the problem, but the daily sugar attacks were destroying your nerves faster than any supplement could ever repair them.
- The three-part biological trap that keeps nerves deteriorating no matter how well you manage your diabetes, and why addressing only one part cannot break it.
- The two-part defense system one functional medicine doctor has been quietly using with her diabetic patients, and what happened in 90 days.
Before I Tell You What I Found, I Need To Tell You Something About The B12 You Probably Already Tried
If you are reading this, there is a very good chance you have taken B12 at some point. Maybe a bottle from Costco. Maybe from the pharmacy. Maybe a sublingual. Maybe for a few months. Maybe for a year.
And it probably did almost nothing. The burning kept burning. The tingling kept spreading. You stopped. You decided B vitamins were overhyped. You moved on.
I want to say something carefully before I go any further, because it is the single thing I wish someone had told me four years ago.
B vitamins were not the wrong answer. The mechanism is real. B1, B6, and B12 are the primary building materials your body uses to rebuild the myelin sheath around damaged nerves. That science is not marketing. It is documented across decades of published research.[14][22]
What happened to you, and what happened to me, is not that B vitamins failed.
What happened is that while the B vitamins were trying to rebuild, something else was destroying those same nerves faster than anything could keep up with. Something that was happening three to five times a day. Something that had nothing to do with your willpower, your diet, or your diabetes management.
Something nobody had ever named for me in eleven years of diabetic care.
That is what Dr. Marsh drew for me on a piece of paper. And that is what I am about to walk you through.
The Night I Realized I Had Been Missing Something For Three Years
I had not seen Diane in almost a year.
She walked into our diabetic support group meeting in Sacramento on a Thursday night in October, and I spent the first ten minutes of the evening trying to figure out what was different about her. It was not her hair. It was not that she had lost weight. It was something I could not name until she reached across the table to grab her coffee mug and I saw it in the way her hand moved.
Steady. Confident. She could feel the mug.
And sitting across from her in a community room I had been in fifty times, I realized something that hit me harder than I was ready for.
I had not felt my own fingertips properly in almost three years.
I had stopped feeling the texture of my husband's shirt when I reached for his hand. I had stopped feeling the warmth of my morning coffee mug. I had stopped feeling the floor under my feet when I walked to the bathroom at night. The burning had started at fifty eight. The numbness crept in at sixty. By sixty one I was on 1800 milligrams of Gabapentin a day and my doctors kept telling me my numbers looked fine.
I had spent three years watching myself deteriorate while being told I was doing everything right.
I stayed after everyone else left that night.
I asked Diane what changed.
The Three Years Nobody Was Willing To Explain
Before I tell you what Diane said, I have to tell you what I had been living with. Because I have since learned there are millions of us, and nobody is talking about it in the words it actually happens in.
It started about two years after my Type 2 diagnosis.
At first it was just a strange burning on the soles of my feet at night. I thought I had stood on a hot surface. Then it was tingling in my fingertips when I held a book. Then it was pins and needles when I crossed my legs too long. Then one morning I realized I could not feel the tile floor under my feet.
I was going numb. From the outside in.
I want to say that carefully, because I think most diabetics with neuropathy know exactly what I mean and have never said it out loud. It is not just the pain. It is not just the burning. It is the quiet, creeping loss of feeling. The dread that wakes you up at two in the morning when your foot has been burning for three hours and you realize the numbness has spread another inch up your leg since last month.
My husband would put his hand on my shoulder in the kitchen and I could barely register his touch. Not because I did not love him. Because the wiring had been disconnected and nobody had told me why.
I tried everything my doctors pushed at me. Gabapentin at 300 milligrams. Then 600. Then 900. Then 1800 a day. B12 pills from Costco. Lyrica for a week before the swelling made me quit. Topical creams. A TENS unit my sister bought me. Three months on each. Nothing reversed. Nothing healed. The numbness kept spreading.
I asked four different doctors over two and a half years. The nicest one patted my hand and said, "Margaret, this is just what happens with diabetes. You have to accept it." One asked if I was really compliant with my Metformin. One suggested I was being "dramatic" and offered me a referral to a psychiatrist. One ran my A1C, told me it was "well-controlled for your age," and said there was nothing more to be done.
None of them tested the three things that actually mattered.
By sixty one, I had accepted it. I thought the independence I had worked my whole life for, the ability to feel my own body, to walk confidently, to hold my grandchildren without fear of dropping them, was gone for good. That was the lowest point I had hit in my adult life.
And it was the point right before Diane walked into the support group meeting.
Does any of this sound familiar?
If three or more feel true, this is not bad diabetes management. This is not you being dramatic. This is not in your head. It is a specific three-part biological trap almost no neurologist is addressing.
"It Is Not Your Blood Sugar Management."
That is what Diane said to me when I asked her what changed.
She said, "Margaret, I thought I was just another diabetic with worsening neuropathy. I thought I was going to end up in a wheelchair. I was wrong. It is not your blood sugar management. I found someone who actually listened to me and she drew the answer on a piece of paper in about ninety seconds."
Her name was Dr. Elena Marsh. A functional medicine doctor in Oakland. Fifty nine years old. Twenty six years in practice. Over eighteen hundred diabetic patients worked with across her career. She specializes in something most endocrinologists politely ignore, which is what actually happens to the nerves of a diabetic over fifty when the standard treatment stops working.
I drove the two hours to her office the following month.
The first thing Dr. Marsh did was not order another A1C.
I remember sitting there on the crinkly paper of the exam table thinking, that is strange, because every other doctor had run one. The A1C is the reflex move in diabetic medicine.[1] But Dr. Marsh did not order one. She ordered three things I had never been tested for in eleven years of diabetic care visits.
A continuous glucose monitor for postprandial spikes. A methylmalonic acid test for actual B12 cellular utilization. And a serum glycation marker panel.[2]
Then she asked me about my meals. What I ate and when. How I felt after eating. How long I had been on Metformin. Whether my B12 had ever been tested since starting it. And then she asked me a question no doctor had ever asked me in that exact way.
"Margaret, when did you last feel your feet on a cold floor in the morning?"
I started to cry right there on the paper.
Because I knew the answer and it had been a very long time ago.
At the end of the appointment she looked at me across her desk and said something I still remember word for word, three years later.
If it was not my blood sugar management, what was it?
Diabetic Neuropathy Is Not A Blood Sugar Story Alone. It Is An Attack Story.
The entire diabetic neuropathy treatment model is built on two sentences.
Control your blood sugar. Take Gabapentin for the pain.
It is half true. You do need to control blood sugar. Roughly 50 percent of diabetics develop some form of neuropathy within 20 years of diagnosis.[3] The pharmaceutical industry has spent billions telling you that if you just manage your glucose better and take your nerve medication, you will be fine. Gabapentin prescriptions for diabetic neuropathy generate over 6 billion dollars annually in the United States.[4]
Here is the question almost nobody in the category is asking out loud.
If blood sugar control and Gabapentin were the whole story, why do so many diabetics with excellent A1C numbers still watch their neuropathy progress? Why do so many patients on Gabapentin report the numbness and burning spreading year after year, even at maximum dose? Why do two diabetics, same age, same A1C, same Metformin, walk out of their diagnosis with two completely different experiences, one with functional feet at seventy and one in a wheelchair at sixty five?
Here is what Dr. Marsh told me that afternoon, and what I have since confirmed with hours of my own research.
Diabetic neuropathy has one real destroyer and two hidden saboteurs. And until all three are addressed together, nothing else works.
The destroyer is the post-meal glucose attack. Three to five times a day, every single day, whether your A1C is controlled or not. This is what is actually breaking down your nerves.[5][8]
The first saboteur is Gabapentin. It does not repair nerves. That is not an opinion. That is pharmacology.[6] It blocks pain signals at the calcium channel level. It turns off the alarm system. But the fire keeps burning underneath, and you cannot feel how bad the damage is getting because the alarm is off.
The second saboteur is Metformin. The medication that controls your blood sugar actively depletes Vitamin B12. Up to 30 percent of long-term Metformin users develop clinical B12 deficiency.[10][11] This is the piece nobody explained. The B12 you were taking from the drugstore was never reaching your nerves at the levels they needed, because the medication you were taking every morning was blocking the absorption.
So the picture actually looks like this. An attack is happening to your nerves after every meal. A medication is hiding the damage. And another medication is preventing the one thing that could repair the damage from being absorbed.
It was not my blood sugar management that had failed. It was not my diet. It was not my willpower. I had been caught in The Diabetic Nerve Trap for a decade, and nobody had ever named the attack that was causing it.
The Attack. The Cover-Up. The Absorption Block.
Here is the picture Dr. Marsh drew for me on a piece of blank printer paper that afternoon. This is the picture no endocrinologist, no neurologist, and no primary care doctor has ever shown me in my life.
One circle in the center, big and red. An attack. Two smaller circles on either side, pointing toward it. Saboteurs. And underneath, three instructions.
Stop the attack. Restore absorption. Repair the nerve.
Here is what she explained to me on the phone two days later, because I had left her office still half confused and too emotional to absorb it the first time.
The Attack: Post-Meal Glucose Spikes Destroying Your Nerves Three To Five Times A Day.
Even with well-controlled blood sugar on Metformin, your body experiences three to five glucose spikes per day after meals. Metformin primarily lowers fasting glucose. It was never designed to stop post-meal spikes.[8] During each spike, a process called glycation occurs. Sugar molecules physically attach to the proteins in your nerve tissue and destroy the myelin sheath, which is the protective coating around every nerve in your body.[9]
Think of it like a house with insulation around the wiring. Every blood sugar spike is sugar molecules stripping that insulation, one meal at a time. Your A1C can look fine. You can be "well-controlled." And your nerves can still be getting attacked three to five times a day, every single day, for years.
This is the real enemy. Everything else is just what prevents you from stopping it.
The Cover-Up: Gabapentin Silencing The Alarm While The Damage Compounds Underneath.
Gabapentin does not repair nerves. It blocks pain signals at the calcium channel level.[6] It turns off the alarm system. But the fire keeps burning.
This is why your symptoms come back or worsen every time you try to reduce the dose. The nerves have not healed. They have just been silenced. Every year on Gabapentin, the damage underneath is compounding while you cannot feel how bad it is getting. This is why the dose keeps going up. The medication does not stop working. The damage beneath it keeps advancing.
The Absorption Block: Metformin Depleting The Very Vitamin Your Nerves Need To Heal.
Here is what most doctors are not telling you. The medication that has been controlling your blood sugar for years is actively depleting Vitamin B12.[10] The longer you have been on Metformin, the more depleted you are. Studies have shown up to 30 percent of long-term Metformin users develop clinical B12 deficiency.[11]
On top of that, high blood sugar itself impairs B vitamin uptake at the cellular level.[12] So the drugstore B12 you took for four months was doing exactly what B12 is supposed to do, but not enough of it was reaching your nerves to make a difference against the attacks happening every day. Diabetics over 50 can absorb up to 40 percent less B vitamins than non-diabetics of the same age.[13]
This is why B12 alone never worked for you. Not because B12 does not work. Because the version you had was not calibrated for a long-term Metformin user with active glucose attacks destroying nerves faster than any standard dose could repair them.
The Trap Can Be Broken. Here Is Why.
Here is what Dr. Marsh said next, and it is the sentence that broke something open in me.
The attack can be stopped. The saboteurs can be worked around. And the moment you do both, your nerves start healing the way they were always supposed to.
Your nerves have the ability to regenerate. The myelin sheath that protects them can be rebuilt. The blood sugar attacks after every meal can be reduced dramatically. The B vitamin absorption gap caused by Metformin can be overcome with the right form and the right clinical potency.[14]
And here is the part that mattered most to me. You do not have to stop Gabapentin. You do not have to stop Metformin. You do not have to replace anything your doctor prescribed.
You have to add the two things your treatment plan was never designed to provide: a defense against the glucose attack, and a nerve repair complex calibrated specifically for a body your Metformin has been quietly depleting for years.
That is exactly what The Complete Nerve Protection System was designed to do.
The Two-Part Defense System That Breaks The Trap
Dr. Marsh had been quietly using a specific two-part protocol with her diabetic neuropathy patients for over two years. She called it a defense system because it does two specific things at the same time. It stops the attack that is breaking down your nerves every time you eat. And it delivers the building blocks your nerves need to rebuild, in clinical potencies calibrated for a body that has been on Metformin for years and absorbs B vitamins forty percent worse than a healthy adult.
The first job stops the destruction. The second job makes the repair finally stick. Neither one works without the other, which is why every previous supplement you tried addressed one side and left the other unprotected.
The system is made by Symbiosfy. It is called The Complete Nerve Protection System, and it is two products designed to work together.
Defense One. Blood Sugar Defense.
This is the product that stops the daily glucose attacks on your nerves. Two capsules, once per day, taken before your largest meal.
It contains Chromium at 420% DV, which is clinically shown to improve insulin sensitivity and smooth post-meal glucose spikes.[15] It contains Gymnema Sylvestre, the ancient Indian herb known as the "sugar destroyer" because it blocks sugar absorption at the intestinal level.[16] It contains Bitter Melon Extract, which mimics insulin activity at the cellular level and has been studied for decades for glucose management.[17]
But the most important ingredient in this formula, and the reason I am telling you this story, is Alpha Lipoic Acid. In Germany, Alpha Lipoic Acid is actually prescribed by doctors for diabetic neuropathy.[18] It is a powerful antioxidant that protects nerve endings from the oxidative stress created by glucose spikes.[19]
Dr. Marsh's words: "You cannot heal nerves while sugar is still attacking them after every meal. You have to stop the attack first."
Defense Two. Nerve Regeneration Complex.
This is the product that actually rebuilds the damaged nerve tissue. Two capsules per day, taken in the morning with food.
It contains the three B vitamins that specifically rebuild the myelin sheath, at the clinical potencies needed to overcome the diabetic absorption gap:
Vitamin B1 (Thiamine) at 583% DV - Reduces nerve inflammation and burning sensations.[20]
Vitamin B6 (Pyridoxine) at 577% DV - Supports neurotransmitter production and nerve-brain signaling.[21]
Vitamin B12 (Cyanocobalamin) at 1125% DV - The primary regenerative B vitamin that rebuilds the myelin sheath.[22]
Plus a full spectrum of supporting cofactors: Folate, Zinc, Selenium, Vitamin D3, and antioxidants that your nerves need to actually complete the regeneration process.[23]
This is not a drugstore B12 pill. The potencies are calibrated specifically for diabetic patients whose absorption is compromised.
Together, they do what Gabapentin cannot. Stop the damage. Repair the nerves. Break the cycle.
Thousands of diabetic patients have already started breaking the Diabetic Nerve Trap with The Complete Nerve Protection System.
See The Defense System →60-day money-back guarantee • Ships from USA
Bundle pricing only available while both products are in stock together.
How To Take The System (Simple Daily Routine)
Note: Always consult your doctor before reducing any prescribed medication, including Gabapentin or Metformin. This system is designed to complement your existing treatment, not replace it. Most users have the conversation about reducing Gabapentin naturally with their doctor at the 60 to 90 day mark.
What The Next 90 Days Actually Looked Like
I want to be honest about how this unfolded. Because the timeline matters. And because I want you to know exactly what to expect, not what a supplement brand would want you to expect.
Dr. Marsh showed me one more chart before I left. She said this was the response curve she had seen in patient after patient over two years of running the protocol.
That curve explained something I had not understood until I saw it laid out.
Sensation is the last thing to come back. Not because it is the least important. Because it is the downstream signal of everything else.
You cannot skip to week 8 sensation return if week 2 glucose attacks have not dropped first. This is why every supplement I had tried before had failed. They skipped the early weeks of the rebuild and tried to land on the last weeks. The body does not work that way.
Here is what each of those weeks actually felt like in my life.
The rebuild is not dramatic. That is maybe the most important thing I can tell you.
It is not a switch you flip. It is the slow, quiet return of the woman who used to feel her own body. The one who could walk confidently. The one who could hold her grandchildren without fear. The one who did not have to ask her husband to help her button her shirt.
She was not gone. She was waiting for the trap to be broken.
I was not the only one. When I joined the Symbiosfy community, I found hundreds of diabetics who had gone through the same rebuild.
These are a few of them."In twenty six years of practice, the three-part nerve trap has been the most consistent blind spot in diabetic care I see. When we address all three parts directly, the patients who had been told their neuropathy was just 'advancing diabetes' start reporting sensation returning. It is not a placebo effect. It is the trap finally being broken."
I was on 1200 mg of Gabapentin for four years. My feet burned every night. I thought it was just my life now. Week seven on The Complete Nerve Protection System, I slept through the night for the first time in two years. At week ten my doctor agreed to reduce my Gabapentin to 600 mg. I can feel my feet again. I can feel the floor.
My A1C was 6.8. My doctors said I was "well-controlled." And my neuropathy was spreading up my calves. When my nurse practitioner friend told me Metformin depletes B12 and I had probably been running on empty for years, I could not believe no one had told me. I added this system to my Metformin. Day forty five the tingling in my hands stopped completely. I am still on Metformin, but I added what was missing.
I could not tolerate Gabapentin because of the brain fog. I had resigned myself to just living with the burning feet. A friend told me about the three-part trap and it was the first explanation that actually matched what I was feeling. I am on week eleven. The burning is 80 percent gone. I feel my feet again. I feel like myself again. Not for my husband. For me.
I tried three different B12 supplements over two years. Nothing. What was different about this system was that my glucose monitor showed smaller post-meal spikes within the first week. The B vitamins finally had a chance to do their job because the sugar attacks stopped. A single B12 pill never touched the glucose piece. Now I understand why.
Over 12,000 diabetic patients have started their 90-day nerve repair protocol.
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The Questions I Had Before I Started
I had the same questions you are probably having right now. Here is how Dr. Marsh answered each one during our calls.
"I have tried B12 supplements before and they did nothing. Why would this be different?"
Most B12 supplements are designed for general adult absorption. When you are diabetic over 50 with Metformin-related B12 depletion and high-blood-sugar-impaired absorption, standard B12 does not reach your nerves at therapeutic levels. The Nerve Regeneration Complex delivers B1 at 583% DV, B6 at 577% DV, and B12 at 1125% DV specifically to overcome diabetic absorption failure. AND it addresses the glucose attacks simultaneously with Blood Sugar Defense, which is the piece standalone B12 never addresses.
"Will this interact with my Metformin or Gabapentin?"
The Complete Nerve Protection System is designed to COMPLEMENT your existing medication, not replace it. Blood Sugar Defense works WITH Metformin to improve post-meal glucose management. The B vitamins in the Nerve Regeneration Complex directly address the B12 depletion that Metformin causes.[10] Always consult your doctor before reducing Gabapentin, but most users find they have that conversation naturally as symptoms improve.
"How long before I see results?"
Most users report reduced burning and tingling within 2 to 3 weeks as the glucose attacks decrease. Noticeable sensation return typically begins at 4 to 6 weeks. Full nerve regeneration develops over 90 days as the myelin sheath rebuilds. This is biological time, not marketing time.
"Am I too far gone at my age?"
Nerve regeneration responds at any age if the three parts of the trap are addressed simultaneously. Dr. Marsh has patients in their seventies and eighties who have seen sensation return. Older nerve damage takes longer to rebuild, but it does rebuild. The 90-day protocol is the minimum commitment regardless of age.
"What if it does not work for me?"
Then the 60-day money-back guarantee covers you fully. If you complete the protocol and you do not feel meaningfully different, you get your money back. No return required. The guarantee matches the biological rebuild window because Symbiosfy means it.
"Why not just buy B12 and chromium separately from Amazon?"
Single-ingredient supplements address one piece of the trap. The Diabetic Nerve Trap requires all three parts addressed at the same time, with the correct potencies and cofactors. You can buy B12 anywhere. You can buy chromium anywhere. You cannot buy the two-part coordinated defense system that addresses all three trap failures. This is a formulated system, not a commodity.
The Compounding Math Of Waiting
Here is the urgency Dr. Marsh closed my first appointment with, and she was right about it.
Diabetic neuropathy is a progressive condition. Once the myelin sheath is destroyed past a certain threshold, the damage becomes permanent and regeneration becomes impossible.[24] Every month you wait, the glucose attacks continue, the Gabapentin continues masking the damage, and the B vitamin gap continues widening. Starting the rebuild today means measurable shifts by week twelve. Starting in six months means you are chasing six more months of compounding damage.
This is not a fake countdown. It is the actual biology of diabetic nerve progression.
The Complete Nerve Protection System
Two products. Two capsules of each per day. Ninety days minimum because that is the biological timeline of nerve regeneration, not a marketing window.
- ✓Addresses the glucose attack and the absorption block at the same time
- ✓Blood Sugar Defense stops glucose attacks on your nerves after every meal
- ✓Chromium 420% DV plus Gymnema, Bitter Melon, Alpha Lipoic Acid
- ✓Nerve Regeneration Complex rebuilds the myelin sheath
- ✓B1 at 583% DV, B6 at 577% DV, B12 at 1125% DV (calibrated for diabetic absorption)
- ✓Full cofactor support with Folate, Zinc, Selenium, Vitamin D3
- ✓Designed specifically for diabetic patients with neuropathy
- ✓Works WITH Metformin and existing medication, not against it
- ✓From Symbiosfy, makers of Colon Reset+ and Inner Calm+
- ✓Backed by a 60-day money-back guarantee
Manufactured in a GMP-certified facility in the USA. Non-GMO. Vegetable capsules. Third-party tested for potency.
You Have Two Choices Right Now
Keep treating neuropathy as "just diabetes" and wait another year
The glucose attacks continue. The Gabapentin dose keeps increasing. The numbness spreads another inch up your legs. The damage becomes more permanent. The category keeps telling you it is just your diabetes. It is not. And waiting is not neutral. It is active deterioration.
Start breaking the trap today and give the protocol 90 days
Address the attack, the absorption block, and the repair all at once. Let the rebuild happen on biological time. See where your body is at the end of the protocol. Risk-free for a full 60 days, money back if it does not work.
Start The 90-Day Nerve Repair Protocol
Two-product system. 60-day money-back guarantee. If you do not feel meaningfully different at the end of the protocol, contact them and they will refund you.
Over 12,000 diabetic patients have started this protocol
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Six Months Later, I Was The One Somebody Was Studying Across A Room
Six months after I sat across from Diane at that support group, I was the one somebody else was watching.
A neighbor I had not seen in two years bumped into me at the grocery store and kept losing her place in the conversation. Finally she stopped and said, "Something is different about you. I can not figure out what it is."
I did not tell her it was the trap. Not yet. You cannot lead with the biology. Nobody is ready for that.
I just said what Diane had said to me on a Thursday night in October.
"I found someone who actually listened."
And then I sent her to the same place I am sending you.
If you have read this far, something in what I wrote lined up with something you are quietly living. I know, because it lined up with me for three years before I found the name for it. You are somewhere in the Diabetic Nerve Trap. Your glucose is attacking your nerves after every meal. Your Gabapentin is masking the damage. Your B vitamins are not absorbing at the levels your nerves need. Your nerves are crying out for help that is not coming from your current treatment.
The person you were before the numbness started is still in there. She is not gone. He is not gone. You are not gone. You are trapped behind three biological failures that nobody has ever named for you.
I am not going to tell you what to do next. I am just going to tell you what I wish someone had told me on the night I stayed up crying on my kitchen floor at sixty one, thinking this was just the rest of my life.
You are not a liar. You are not dramatic. You are not exaggerating. You are not being non-compliant. Your pain is real. Your numbness is real. Your fear is justified.
And the trap can be broken.
She is still in there. Go get her back.
Start Breaking The Trap Today
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Over 12,000 diabetic patients have already started
From the makers of Colon Reset+ and Inner Calm+ • Symbiosfy
— Margaret
Frequently Asked Questions
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References & Medical Citations
- 1.American Diabetes Association. Standards of Medical Care in Diabetes - 2023. Diabetes Care. 2023;46(Suppl 1):S1-S291. https://diabetesjournals.org/care/issue/46/Supplement_1
- 2.Stabler SP. Vitamin B12 deficiency. N Engl J Med. 2013;368(2):149-160. https://doi.org/10.1056/NEJMcp1113996
- 3.Pop-Busui R, Boulton AJM, Feldman EL, et al. Diabetic Neuropathy: A Position Statement by the American Diabetes Association. Diabetes Care. 2017;40(1):136-154. https://doi.org/10.2337/dc16-2042
- 4.Goodman CW, Brett AS. Gabapentin and Pregabalin for Pain - Is Increased Prescribing a Cause for Concern? N Engl J Med. 2017;377(5):411-414. https://doi.org/10.1056/NEJMp1704633
- 5.Feldman EL, Callaghan BC, Pop-Busui R, et al. Diabetic neuropathy. Nat Rev Dis Primers. 2019;5(1):41. https://doi.org/10.1038/s41572-019-0092-1
- 6.Wiffen PJ, Derry S, Bell RF, et al. Gabapentin for chronic neuropathic pain in adults. Cochrane Database Syst Rev. 2017;6(6):CD007938. https://doi.org/10.1002/14651858.CD007938.pub4
- 7.Ziegler D, Papanas N, Schnell O, et al. Current concepts in the management of diabetic polyneuropathy. J Diabetes Investig. 2021;12(4):464-475. https://doi.org/10.1111/jdi.13401
- 8.Monnier L, Lapinski H, Colette C. Contributions of fasting and postprandial plasma glucose increments to the overall diurnal hyperglycemia of type 2 diabetic patients. Diabetes Care. 2003;26(3):881-885. https://doi.org/10.2337/diacare.26.3.881
- 9.Sugimoto K, Yasujima M, Yagihashi S. Role of advanced glycation end products in diabetic neuropathy. Curr Pharm Des. 2008;14(10):953-961. https://doi.org/10.2174/138161208784139774
- 10.de Jager J, Kooy A, Lehert P, et al. Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial. BMJ. 2010;340:c2181. https://doi.org/10.1136/bmj.c2181
- 11.Aroda VR, Edelstein SL, Goldberg RB, et al. Long-term Metformin Use and Vitamin B12 Deficiency in the Diabetes Prevention Program Outcomes Study. J Clin Endocrinol Metab. 2016;101(4):1754-1761. https://doi.org/10.1210/jc.2015-3754
- 12.Reinstatler L, Qi YP, Williamson RS, Garn JV, Oakley GP Jr. Association of biochemical B12 deficiency with metformin therapy and vitamin B12 supplements: the National Health and Nutrition Examination Survey, 1999-2006. Diabetes Care. 2012;35(2):327-333. https://doi.org/10.2337/dc11-1582
- 13.Allen LH. How common is vitamin B-12 deficiency? Am J Clin Nutr. 2009;89(2):693S-696S. https://doi.org/10.3945/ajcn.2008.26947A
- 14.Sun Y, Lai MS, Lu CJ. Effectiveness of vitamin B12 on diabetic neuropathy: systematic review of clinical controlled trials. Acta Neurol Taiwan. 2005;14(2):48-54. https://pubmed.ncbi.nlm.nih.gov/16008162/
- 15.Anderson RA. Chromium, glucose intolerance and diabetes. J Am Coll Nutr. 1998;17(6):548-555. https://doi.org/10.1080/07315724.1998.10718802
- 16.Tiwari P, Mishra BN, Sangwan NS. Phytochemical and pharmacological properties of Gymnema sylvestre: an important medicinal plant. Biomed Res Int. 2014;2014:830285. https://doi.org/10.1155/2014/830285
- 17.Krawinkel MB, Keding GB. Bitter gourd (Momordica Charantia): A dietary approach to hyperglycemia. Nutr Rev. 2006;64(7 Pt 1):331-337. https://doi.org/10.1111/j.1753-4887.2006.tb00217.x
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* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. References cited above relate to ingredient-level published research and the underlying endocrinology of diabetic neuropathy. They are not claims about this specific product formulation.